Contact Will Pearson

William H. Pearson, Ph.D.
Pearson Chemistry Solutions
Raleigh, North Carolina

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  • Regioselective synthesis of 3- and 5-aminopyrazoles August 6, 2015
    Just a bit of sodium ethoxide does the trick … The Knorr pyrazole synthesis, broadly defined, involves the condensation of hydrazines with 1,3-dielectrophiles, e.g., 1,3-diketones, beta-ketoesters, alpha-cyanoketones, beta-alkoxyacrylonitriles, alkoxymethylenemalonates, etc. When a nitrile electrophile is involved, an aminopyrazole typically results, producing compounds that are very useful in the pharmaceutical field. The first two equations in the […]

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