Why This Course?

This powerful course provides your team with high-value insights on the synthesis of heterocyclic compounds encountered in the biotech, pharmaceutical, and agricultural industries.

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Who will benefit from this course?

Chemists at all levels involved in any aspect of the design, synthesis, or manufacture of heterocyclic organic compounds will strengthen and update their background in heterocyclic chemistry. Those who have not had formal training in heterocyclic chemistry will find the lectures and course materials useful in bringing their level of knowledge up to that necessary to operate effectively in the field. Those who have expertise in heterocyclic chemistry will be able to update and otherwise complement their existing knowledge. Upon completion of the course, participants will be able to propose reasonable synthetic routes to even unfamiliar heterocycles as well as make predictions about their reactivity and properties.

Heterocyclic Chemistry, Simplified

Our training as organic chemists typically focuses on carbon chemistry with heterocyclic chemistry sprinkled in here and there.  Yet in the industrial endeavor, most chemists find themselves engaged in heterocyclic chemistry because of their biological relevance.  It can be daunting to tackle your project and the field of heterocyclic chemistry at the same time.  Who has time to delve deeply into this complex area and gain important insights, understanding, and organizational principles?  In this course, the distillation and organization has been done for you. In short order, you will gain simplifying insights and key knowledge on the structure, reactivity, and synthesis of heterocyclic compounds.

Best Synthetic Methods

What are the best ways to make heterocycles, especially considering current or future scale-up issues?  The course focuses on methods and routes that are tested, well- regarded, reliable, and scaleable.  Many of the examples are taken from preparatively-oriented articles that prove the utility of a given method.  Kilograms, not milligrams.  You will not hear about exotic, tricky, unproven chemistry unless it’s an up-and-coming area that your instructor thinks has practical potential.

Relevant Heterocycles

There are millions of known heterocycles and no course can hope to cover them all.  If you’re a pharmaceutical or agricultural researcher, you probably don’t want to hear about heterocycles from materials science, nanoscience, high-energy materials, etc.; you want examples that relate to your field.  Specifically, you want to see heterocycles of the type you’re actually working on.  To achieve good relevance, the course examples are largely taken from the pharmaceutical field.  Past course participants have found that the breadth of examples in the course have led to new ideas for their projects.  But what about your specific heterocycle?  You may not see it, since it is unlikely that the course will anticipate the thousands of new (proprietary!) targets under investigation in the industry.  Nonetheless, since the course focuses largely on how to make heterocycles, you will come away with ideas and insights about your particular compounds.  It should be noted that company-specific modules are also an option.  Will can extend the course to talk about the synthesis of compounds that are under investigation (or planned) in your company.

Great Course Notes

Long after the course is done, the notes will live on as a reference source. Highly organized and easy to use, the notes comprise over 400 pages of relevant chemical examples and highly-selected, informative, and useful literature citations.  Many of the examples are taken from preparatively-oriented papers (e.g., Org. Proc. Res. Dev., J. Med. Chem., etc.) so you will not have to weed through irrelevant, exotic examples of the type found in many heterocyclic chemistry resources.  Further, the examples show full molecular structures and provide conditions, yields, product ratios, and often the scale of the reactions.  Finally, great care has been taken to keep the material up-to-date and organized in order to make it easy to find the information you’re looking for.

When the Literature Fails You…

You’ve looked for your specific heterocycle in the literature and not found it.  You’ve looked at analogous heterocycles and nothing has panned out.  Or you’ve found a promising literature method but it doesn’t work or won’t scale up.  And you haven’t seen your specific target in this course.  Now what?  A major feature of this course is it’s focus on how to form the various bonds in heterocycles.  Retrosynthetic analysis and “electronic disconnection” are used as organizational concepts, enabling you to propose viable synthetic routes to novel (or problematic) heterocycles.

Top-Notch Instruction

Will Pearson is an award-winning researcher and teacher in the field of heterocyclic chemistry. He has over thirty yearsʼ experience and over 120 publications in the area.  One of Will’s core skills is the process of delving deeply into an area, critically analyzing it, distilling it down to its key elements, and sharing those elements with others in a clear and effective manner.  He has presented dozens of well-received training courses in companies worldwide.  His twenty years of teaching chemistry at the University of Michigan combined with his experience working in the chemical industry have given him the skills and perspective necessary for the development and presentation of highly effective training courses for company scientists. Will is sure to leave you and your colleagues with an effective understanding of this topic. 

Read about Will Pearson


RSS Heterocyclist Blog

  • Regioselective synthesis of 3- and 5-aminopyrazoles August 6, 2015
    Just a bit of sodium ethoxide does the trick … The Knorr pyrazole synthesis, broadly defined, involves the condensation of hydrazines with 1,3-dielectrophiles, e.g., 1,3-diketones, beta-ketoesters, alpha-cyanoketones, beta-alkoxyacrylonitriles, alkoxymethylenemalonates, etc. When a nitrile electrophile is involved, an aminopyrazole typically results, producing compounds that are very useful in the pharmaceutical field. The first two equations in the […]

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