Clarity in a Complex Field
Make & Modify Heterocyclic Compounds.
Proven methods.
Real world examples.

the premiere industry course

This powerful course provides your team with high-value insights on the synthesis of heterocyclic compounds of the type encountered in the biotech, pharmaceutical, and agricultural industries.


The distillation and organization has been done for you. Gain simplifying insights and key knowledge on the structure, reactivity, and synthesis of heterocyclic compounds. Read more »

Best Synthetic Methods

Learn which methods and routes are tested, well-regarded, reliable, and scalable. Kilograms, not milligrams. Read more »

Relevant Heterocycles

Course examples and case-studies are largely taken from the pharmaceutical field. An optional company-specific module is available that addresses your area. Read more »

"I was very impressed by the breadth of references and reviews listed. I really liked Will's approach to teaching how to think about different bond disconnections. This helped me simplify how I think about these problems.”
– N.B., West coast discovery chemist
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Great Course Notes

Long after the course is done, the notes will live on. Over 400 pages of relevant chemical examples and highly-selected, informative, and useful literature citations. Read more »

Top-Notch Instruction

Will Pearson is an award-winning researcher and engaging teacher in the field of heterocyclic chemistry. Read more »

When All Else Fails...

When literature routes and analogies are not useful, use retrosynthetic analysis to propose a reasonable
route to your new compound. Read more »


RSS Heterocyclist Blog

  • Regioselective synthesis of 3- and 5-aminopyrazoles August 6, 2015
    Just a bit of sodium ethoxide does the trick … The Knorr pyrazole synthesis, broadly defined, involves the condensation of hydrazines with 1,3-dielectrophiles, e.g., 1,3-diketones, beta-ketoesters, alpha-cyanoketones, beta-alkoxyacrylonitriles, alkoxymethylenemalonates, etc. When a nitrile electrophile is involved, an aminopyrazole typically results, producing compounds that are very useful in the pharmaceutical field. The first two equations in the […]

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